Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Blood-brain barrier transport: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Waste Clearance | involved_in | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Magnetosonic-Triggered Transferrin Receptor Clustering | 0.470 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.443 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] | Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu | Cell Stem Cell | 2025 | 1 |
| Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] | Sehlin D, Hultqvist G, Michno W, Aguilar | J Prev Alzheimers Dis | 2025 | 1 |
| Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] | Kempuraj D, Dourvetakis KD, Cohen J, Val | Front Cell Neurosci | 2024 | 1 |
| The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] | Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T | Int J Mol Sci | 2023 | 1 |
| Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] | Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z | Exp Neurol | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333] | Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z | Nature | 2021 | 1 |
| On Iron Metabolism and Its Regulation. [PMID:33925597] | Vogt AS, Arsiwala T, Mohsen M, Vogel M, | Int J Mol Sci | 2021 | 1 |
| APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954] | Montagne A, Nation DA, Sagare AP, Barisa | Nature | 2020 | 1 |
| Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] | Feng H, Schorpp K, Jin J, Yozwiak CE, Ho | Cell Rep | 2020 | 1 |
| Transferrin and transferrin receptors update. [PMID:29969719] | Kawabata H | Free Radic Biol Med | 2019 | 1 |
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033] | Levey J, Howe M, Douglas K, Odame E, Raj | bioRxiv : the preprint server | 2026 | 0 |
| Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] | Nell LM, Hendriks RW, Wijsenbeek MS, Cor | Eur Respir Rev | 2026 | 0 |
| Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335] | Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha | Research (Washington, D.C.) | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656] | Jansson D, Highet B, Li S, Stevenson TJ, | Molecular brain | 2026 | 0 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623] | Chen S, Qi T, Peng H, Kimura E, Zhang X | J Control Release | 2026 | 0 |
| Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877] | Lu Y, Zhang Y, Niu C | Comp Biochem Physiol A Mol Int | 2026 | 0 |